Tube tip detection systems, enteral tubes, and methods for detecting tube misplacement in a patient's airway are provided. For example, a tube tip detection system comprises an enteral tube having a tip, a first sensing component disposed at the tip, and a feedback display. Feedback from the first sensing component is displayed on the feedback display to indicate to a user of the tube tip detection system whether the tip is misplaced in a patient's airway. Similarly, an enteral tube comprises a tip, a length, and a sensing component. The sensing component is a micro-electro-mechanical system (MEMS) infrared carbon dioxide sensor. Further, a detection method comprises embedding a carbon dioxide sensing component into an enteral tube, inserting the enteral tube into the patient through the patient's nose or mouth, and monitoring feedback from the carbon dioxide sensing component to determine if the enteral tube is traveling into the patient's airway.
