Mount Sinai School of Medicine of New York University
发明人:
Jian-Qiang Fan,Satoshi Ishii,Naoki Asano
申请号:
US13867914
公开号:
US20140051725A1
申请日:
2013.04.22
申请国别(地区):
US
年份:
2014
代理人:
摘要:
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method are imino sugars and related compounds. In particular, C8-12-alkyl derivatives of N-alkyl-deoxynojirimycin, isofagomine compounds, and calystegine compounds are effective to enhance glucocerebrosidase activity.