PROCEDES D'ELIMINATION DE CONTAMINANTS VIRAUX DANS DES EXTRAITS PANCREATIQUES

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专利权人:

APTALIS PHARMA LTD.

发明人:

ORTENZI, GIOVANNI,GHIDORSI, LUIGI

申请号：

CA2947998

公开号：

CA2947998A1

申请日:

2015.06.19

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

Methods for screening pancrelipase for RNA virus contamination comprise removing free viral RNA from the pancrelipase, denaturing any viruses in the pancrelipase to release encapsidated RNA into the pancrelipase milieu, and detecting this released RNA. Removal of free viral RNA may comprise treating pancrelipase with RNase and DNase or precipitating the protein fraction of pancrelipase with a salt that precipitates the protein fraction while leaving nucleic acids such as RNA in solution. Pancrelipase substantially devoid of free nucleic acid is also provided.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/