GORE VINAYAK G.,GADAKAR MAHESH,POKHARKAR K.,WAKCHURE V.
申请号：
SI200730932
公开号：
SI2044099T1
申请日:
2007.06.11
申请国别(地区):
SI
年份:
2012
代理人:
摘要：
The present invention relates to a process for the preparation of steroidal 17²-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17²-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.
