Sposób wytwarzania S-fluorometylo-6,9-difluoro-11-hydroksy-16-metylo-17-propionyloksy-3-okso-androsta-1,4-dieno-17-karbotionianu oraz związki pośrednie
GORE, VINAYAK G.,GADAKAR, MAHESH,POKHARKAR, K.,WAKCHURE, V.
申请号：
PL07733749
公开号：
PL2044099T3
申请日:
2007.06.11
申请国别(地区):
PL
年份:
2012
代理人:
摘要：
The present invention relates to a process for the preparation of steroidal 17²-carboxylic thioates. More particularly the present invention relates to a convenient and efficient synthesis of steroidal 17²-carboxylic thioates, such as fluticasone propionate I, using soluble mixed fluorides to introduce fluorine by displacing an appropriate leaving group X in compounds II resulting in selective and controlled fluorination. The present invention also relates to intermediates II and their preparation.
