Katrin Spiegel;Kamlesh Jagdis Bala;Edward Charles Hall;Rebecca Butler;Lee Edwards;Stephen Paul Collingwood;Darren Mark Legrand
发明人:
Kamlesh Jagdis Bala,Rebecca Butler,Stephen Paul Collingwood,Edward Charles Hall,Lee Edwards,Darren Mark Legrand,Katrin Spiegel
申请号：
US14343861
公开号：
US09034879B2
申请日:
2012.09.14
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides pyridin-oxadiazole/thiadiazole derivatives of Formula I wherein A is N or CR 4a； and (ii) or (iii) which restore or enhance the function of mutant and/or wild type CFTR to treat cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia and keratoconjunctivitis sire, or constipation (IBS, IBD, opioid induced). Pharmaceutical compositions comprising such derivatives are also encompassed.
