BHALAY, GURDIP,BUDD, EMMA,BLOOMFIELD, GRAHAM CHARLES,COLLINGWOOD, STEPHEN PAUL,DUNSTAN, ANDREW,EDWARDS, LEE,GEDECK, PETER,HOWSHAM, CATHERINE,HUNT, PETER,HUNT, THOMAS ANTHONY,OAKLEY, PAUL,SMITH, NICHOL
申请号：
NZ58578908
公开号：
NZ585789A
申请日:
2008.12.09
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
The disclosure relates to pyrazine-2-carboxamide derivatives such as 3,5-diamino-6-chloro-pyrazine-2-carboxylic acid[8-[6-(3-isopropyl-ureido)-pyridine-3-carbonyl]-1,3,8-triaza-spiro[4 .5]dec-(2E)-ylidene]-amide represented by the structural formula shown herein. These compounds are suitable for the treatment of an inflammatory or allergic condition selected from cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, respiratory tract infections, lung carcinoma, xerostomia, and keratoconjunctivitis sire.
