SMITH, Mark,TALAMAS, Francisco Xavier,ZHANG, Jing,ZHANG, Zhuming
申请号：
ES12808791
公开号：
ES2626484T3
申请日:
2012.12.17
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound of Formula I ** Formula ** wherein: R1 is H, C1-7 haloalkyl, or aryl, wherein the aryl is phenyl or naphthyl, optionally substituted by one or more C1-7 alkyl, C2-7 alkenyl, C2-7 alkynyl, C1-7 alkoxy, halo, C1-7 haloalkyl, -N (R1a) 2, acylamino, -SO2N (R1a) 2, -COR1b, - SO2 (R1c), -NHSO2 (R1c), nitro or cyano； each R1a is independently H or C1-7 alkyl； each R1b is independently -OR1a or -N (R1a) 2； each R1c is C1-7 alkyl； R2a and R2b are independently H or C1-7 alkyl； R3 is C1-7 alkyl, phenyl, or phenyl C1-7 alkyl； R4 is H, C1-7 alkyl, or R2b and R4 together form (CH2) 3； R5 is H, C (>； = O) R1c, C (>； = O) R1b, P (>； = O) (OR1) (OR1a), or P (>； = O) (OR1) (NR4R7)； and R6 is ** Formula ** or a pharmaceutically acceptable salt thereof.Un compuesto de Fórmula I**Fórmula** en donde: R1 es H, haloalquilo C1-7, o arilo, en donde el arilo es fenilo o naftilo, opcionalmente sustituido por uno o más alquilo C1-7, alquenilo C2-7, alquinilo C2-7, alcoxi C1-7, halo, haloalquilo C1-7, -N(R1a)2, acilamino, -SO2N(R1a)2, -COR1b, - SO2(R1c), -NHSO2(R1c), nitro o ciano； cada R1a es independientemente H o alquilo C1-7； cada R1b es independientemente -OR1a o -N(R1a)2； cada R1c es alquilo C1-7； R2a y R2b son independientemente H o alquilo C1-7； R3 es alquilo C1-7, fenilo, o fenil alquilo C1-7； R4 es H, alquilo C1-7, o R2b y R4 forman juntos (CH2)3； R5 es H, C(>；=O)R1c, C(>；=O)R1b, P(>；=O)(OR1)(OR1a), o P(>；=O)(OR1)(NR4R7)； y R6 es**Fórmula** o una sal farmacéuticamente aceptable del mismo.
