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AN IMPROVED PROCESS FOR THE PREPARATION OF PHARMACOPOEIAL GRADE INTERFERON ALPHA 2B
专利权人:
发明人:
DR SANJEEV KUMAR SHARMA,MR SURYA BHUSHAN KUMAR,MR ROHAN PARAB,MR MOHANISH KANKONKAR,MS CONCHITA D SOUZA,DR SACHIN BACHATE,DR RATNESH SHARMA
申请号:
IN3627/MUM/2014
公开号:
IN2014MU03627A
申请日:
2014.11.18
申请国别(地区):
IN
年份:
2016
代理人:
摘要:
The present invention relates to a simple and scalable process for the production of pharmacopoeial grade Interferon alpha 2b by fed- batch fermentation followed by purification using chromatography techniques. The invention also relates to the recombinant expression of interferon alpha 2b in soluble form by fermentation to obtain high yields. The process involves clarification and chromatographic steps for the purification of Interferon alpha 2b.
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