Disclosed herein are compositions and methods to treat hepatocellular carcinoma. In one embodiment, a method of treating a subject with hepatocellular carcinoma comprises administering a therapeutically effective amount of an immunoconjugate (VB4- 845) comprising an antibody conjugated to an effector molecule, and wherein the antibody recognizes epithelial cell adhesion molecule (Ep-CAM). The effector molecule may be