COMMISSARIAT À LÉNERGIE ATOMIQUE ET AUX ÉNERGIESALTERNATIVES
发明人:
LEONETTI, MICHEL,LAMOURETTE, PATRICIA,VOLLAND, HERVÉ,SAVATIER, ALEXANDRA,WIJKHUISEN, ANNE
申请号：
EP13828816.2
公开号：
EP2925357A1
申请日:
2013.11.26
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
A method for the in vitro immunization of human B lymphocytes, comprising culturing a total mononuclear cell population of human peripheral blood in the presence of an antigenic composition comprising at least one antigen covalently bonded to both: (i) a Tat protein or a Tat fragment capable of oligomerization and (ii) a ligand of a surface molecule specific to the antigen presenting cells a method for producing antigen-specific human antibodies derived from said in vitro immunization method.
