The present invention provides araminone compounds of formula (I), their preparations and pharmaceutical compositions containing them. The compounds of formula (I) will be useful for the treatment and/or prevention from of various diseases relating to platelet activating factor (PAF), especially for the therapy of acute and chronic inflammation, such as osteoarthritis, rheumatoid arthritis and the like.本發明公開了一類通式(I)所示的芳胺酮類化合物,這類化合物的製備,含有它們的藥物組合物以及這類化合物在預防和/或治療和血小板活化因數相關疾病中的應用,尤其是在抗炎免疫方面的用途,特別是用於治療急慢性炎症,如骨關節炎、類風濕性關節炎等。;