A catheter including an elongate shaft having a distal end portion locatable within or otherwise proximate to a body lumen of a patient, the catheter having a delivery state and a deployed state, and a tether secured to the neuromodulation unit and operationally associated with the shaft. The neuromodulation unit includes a therapeutic element and a support structure carrying the therapeutic element. The support structure is configured to resiliently urge the therapeutic element radially outward relative to a longitudinal axis of the support structure. The tether is sufficiently flexible to allow the neuromodulation unit to move independently of the distal end portion of the shaft when the catheter is in the deployed state and the neuromodulation unit is within the body lumen.
