Stefan Barghorn,Heinz Hillen,Boris Labkovsky,Andreas R. Striebinger,Patrick Keller,Ulrich Ebert
申请号：
US11574876
公开号：
US08691224B2
申请日:
2006.11.30
申请国别(地区):
US
年份:
2014
代理人:
摘要：
Anti-Aβ globulomer antibodies, antigen-binding moieties thereof, corresponding hybridomas, nucleic acids, vectors, host cells, methods of producing said antibodies, compositions comprising said antibodies, uses of said antibodies and methods of using said antibodies.The present invention relates to anti-Aβ globulomer antibodies having a binding affinity to Aβ(20-42) globulomer that is greater than the binding affinity of the antibody to Aβ(1-42) globulomer, antigen-binding moieties thereof, hybridomas producing said antibodies, nucleic acids encoding said antibodies, vectors comprising said nucleic acids, host cells comprising said vectors, methods of producing said antibodies, compositions comprising said antibodies, therapeutic and diagnostic uses of said antibodies and corresponding methods relating to Alzheimers disease and other amyloidoses.
