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PROCESS FOR THE PREPARATION OF PLEUROMUTILINS
专利权人:
NABRIVA THERAPEUTICS AG
发明人:
RIEDL ROSEMARIE,HEILMAYER WERNER,SPENCE LEE
申请号:
ZA201208056
公开号:
ZA201208056B
申请日:
2012.10.25
申请国别(地区):
ZA
年份:
2014
代理人:
摘要:
A process for the preparation of a compound of formula in the form of a single stereoisomer, comprising deprotecting the amine group in an N-protected amino-hydroxy-cyclohexylsulfanyl-acetyl-mutilin of formula wherein R is an amine protecting group in the form of a single stereoisomer, and isolating a compound of formula I in the form of a single stereoisomer obtained from the reaction mixture; compounds obtainable by such processes, e.g. a compound of formula I in a crystalline form, or salts of a compound of formula I in crystalline form, and processes for the preparation of intermediates for the production of a compound of formula I.
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