This invention, the peptide of WNT10 origin, and the dehairing improvement constituent and the skin improvement constituent which include this, regards the constituent for remedy of WNT10 signal transmission path-related disease, and the DKK 1 protein inviting generation disease. The peptide of WNT10 origin of this invention, equality with the natural WNT10 protein or possessing the function which resembles, stability is superior very by comparison with the natural WNT10 protein, is superior very to skin transmittance. Therefore, for example as for the constituent which includes the peptide of this invention, improvement of dehairing (, the effect promotion of the hair growing or generation of the hair) not only possessing the effect which is superior very, excels in remedy of the WNT10 signal transmission path-related disease and the DKK 1 protein inviting generation disease is shown. In addition, because it is superior in activity and stability, the item outside the medicine and the medicine and applying to the cosmetics very profitably can do the peptide of this invention.< Choice figure >Drawing 12本発明は、WNT10由来のペプチド、並びにこれを含む脱毛改善組成物、皮膚改善組成物、WNT10シグナル伝達経路関連疾患、及びDKK-1蛋白質誘発性疾患の治療用組成物に関する。本発明のWNT10由来のペプチドは、天然のWNT10蛋白質と同一あるいは類似した機能を有して、安定性が天然のWNT10蛋白質と比較して非常に優れており、皮膚透過度に非常に優れている。したがって、本発明のペプチドを含む組成物は、脱毛の改善(例えば、発毛の促進又は毛髪の生成)に非常に優れた効能を有するだけではなく、WNT10シグナル伝達経路関連疾患及びDKK-1蛋白質誘発性疾患の治療に卓越した効能を発揮する。また、本発明のペプチドは、活性及び安定性に優れるため、医薬、医薬外品及び化粧品に非常に有利に適用することができる。【選択図】図12
