This invention hitochimoshin 4 which includes specification amino acid arrangement (T 4) regards peptide and its use which show activity. The human T 4 origin peptide of this invention function or the action which is identical with person T 4 being possible, the degree of physiological activity natural chimoshin 4 (T 4) with is almost equal level. In addition, as for the T 4 origin peptide of this invention, by comparison with nature T 4, it is superior very in stability, also skin permeability is very high. Therefore, the composition which includes the peptide of this invention remedies the disease or a state where T 4 activity is required, makes prevent or improves shows the effect which is superior very. In addition, the item outside the medicine and the medicine, be able to apply to the cosmetics, the tooth polishing, the composition buccal cavity pure or the composition for buccal cavity protection the peptide of this invention, very profitably, it is most desirable, is applied to the cosmetics. Especially, it is desirable to apply to the cosmetics of hair promotion use.< Selective figure >Figure 5本発明は、特定アミノ酸配列を含むヒトチモシンβ-4(Tβ4)の活性を示すペプチド及びその用途に関する。本発明のヒトTβ4由来ペプチドは、ヒトTβ4と同一な機能または作用ができて、その生理活性度も天然チモシンβ-4(Tβ4)とほぼ等しい水準である。また、本発明のTβ4由来ペプチドは、天然Tβ4と比較し、安定性に非常に優れ、皮膚透過度も非常に高い。したがって、本発明のペプチドを含む組成物は、Tβ4活性が要求される疾患または状態を治療、予防または改善するに非常に優れた効能を発揮する。また、本発明のペプチドは、医薬、医薬外品、化粧品、歯磨き、口腔清浄用組成物または口腔保護用組成物に非常に有利に適用でき、最も好ましくは、化粧品に適用される。特に、毛髪促進用途の化粧品に適用することが好ましい。【選択図】図5
