The present invention concerns a composition comprising a combination of a protein material, and a plant or fish oil, wherein the protein material is chosen from the group comprising single cell protein material (SCP), fish protein hydrolysate, or a fermented soy protein material, preferably Gendaxin®. The invention also relates to the use of such a composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of hypercholesterolemia and conditions negatively effected by high cholesterol levels, insulin resistance, obesity, diabetes, fatty liver, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders.
