GUAN, HUIPING,LIANG, CONGXIN,SUN, LI,TANG, PENG CHO,WEI, CHUNG CHEN,MAURAGIS, MICHAEL A.,VOJKOVSKY, TOMAS,JIN, QINGWU,HERRINTON, PAUL MATTHEW
申请号:
CA2438314
公开号:
CA2438314C
申请日:
2002.02.15
申请国别(地区):
CA
年份:
2012
代理人:
摘要:
The present invention relates to pyrrole substituted 2-indolinonecompounds:(see formula I)wherein R1, R2, R3, R4, R5, R6, R7 and Z are as defined herein, and theirpharmaceutically acceptable salts which modulate the activity of proteinkinasesand therefore are expected to be useful in the prevention or treatment ofproteinkinase related cellular disorders such as cancer.