BIOMED VALLEY DISCOVERIES, INC.;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN
发明人:
Saurabh Saha,Xiaoyan M. Zhang,Dimiter Dimitrov,Zhongyu Zhu,Brad St. Croix,Enrique Zudaire
申请号：
US15317069
公开号：
US20170101464A1
申请日:
2015.06.09
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer, in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment of the present invention, and (b) a therapeutically effective amount of a combination therapy including bevacizumab and at least one additional therapeutic agent； or a therapeutically effective amount of at least one additional therapeutic agent selected from the group consisting of a COX-2 inhibitor (COXIB), a non-steroidal anti-inflammatory drug (NSAID), a prostaglandin E2 (PGE2) synthase inhibitor, and combinations thereof. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
