PROBLEM TO BE SOLVED: To provide a small-caliber vascular prosthesis having an inner diameter of at most 6 mm when a vascular prosthesis that employs PET fibers, polybutylene terephthalate fibers, or other aromatic polyester fibers made by reacting an aromatic dicarboxylic acid and an aliphatic diol is connected to an in situ blood vessel, that does not produce thrombi or become occluded over a long period of time, and to provide a very safe vascular prosthesis having an inner diameter of at least 7 mm in which PET fibers, which have been put to practical use in the past, serve as a base material, wherein thickening of a thrombus layer and occlusion are prevented at a branched site, bent site, or anastomosis site.SOLUTION: With the vascular prosthesis in which a tubular article having a knitted fabric, woven fabric, or nonwoven fabric made of aromatic polyester fibers as the base material is coated with or impregnated and coated with a polyamino acid urethane resin, an endothelial cell membrane is formed when the vascular prosthesis is connected to an in situ blood vessel and blood flows through, and since no thrombus occur thereon, the problem can be resolved.COPYRIGHT: (C)2013,JPO&INPIT【課題】PET繊維、またはポリブチレンテレフタレート繊維等、芳香族系ジカルボンサンと脂肪族ジオールとの反応で造られた芳香族系ポリエステル繊維を用いた人工血管を生体血管に繋いだ時に、内径6mm以下の小口径人工血管において、血栓を生じず、長期にわたり閉塞しない人工血管の提供。および実用化されている従来のPET繊維を基材とした内径7mm以上の人工血管においても、枝分かれした部分、屈曲した部分または吻合部において血栓層が厚くなり閉塞することを防止し、より安全性の高い人工血管の提供。【解決手段】芳香族系ポリエステル繊維の編物、織物、または不織布を基材とした管状物にポリアミノ酸ウレタン樹脂をコーティング、または含浸被覆した人工血管は、生体血管に繋いで血液が流れた時内皮細胞膜が形成され、その上には血栓が生じないので、上記課題を解決できる。【選択図】なし
