COX, PAUL JOSEPH,MAJID, TAHIR NADEEM,LAI, JUSTINE YEUN QUAI,MORLEY, ANDREW DAVID,AMENDOLA, SHELLEY,DEPRETS, STEPHANIE,EDLIN, CHRIS
申请号：
CA2699568
公开号：
CA2699568C
申请日:
2000.12.27
申请国别(地区):
CA
年份:
2013
代理人:
摘要：
The invention is directed to compositions containing physiologically active compounds of general formula (I) (see formula I) wherein R1 is aryl or heteroaryl； R2 represents hydrogen, acyl, cyano, halo, lower alkenyl or lower alkyl optionally substituted by a substituent selected from cyano, heteroaryl, heterocycloalkyl, -Z1R8,-C(=O)-NY3Y4,-CO2R8,-NY3Y4,-N(R6)-C(=O)- R7, -N(R6)-C(=O)-NY3Y4,-N(R6)-C(=O)-OR7, -N(R6)-SO2-R7,-N(R6)-SO2-NY3Y4 and one or more halogen atoms； R3 represents hydrogen, aryl, cyano, halo, heteroaryl, lower alkyl, -C(=O)-OR5 or -C(=O)-NY3Y； and X1 represents N, CH, C-halo, C-CN, C-R7, C-NY3Y4, C-OH, C-Z2R7, C-C(=O)-OR5, C-C(=O)-NY3Y4, C-N(R8)-C(=O)- R7, C-SO2-NY3Y4, C-N(R8)-SO2-R7, C-alkenyl, C-alkynyl or C-NO2； and their produgs, and pharmaceutically acceptable salts and solvates of such compounds and their produgs, as well as to novel compounds within the scope of formula (I). Such compounds and compositions have valuable pharmaceutical properties, in particular the ability to inhibit protein kinases.
