The present invention provides a method of diagnosing, prognosticating, predicting or detecting pre-cancer, colorectal cancer (CRC) tumor progression, or metastasis in a human subject comprising the steps of:(a) determining in a biological sample from said human subject the methylation status of at least one CpG in the miR-200ba429 promoter region and/or the miR-200c141 promoter region, and(b) determining the methylation status of one or more of said at least one CpG,(c) determining the risk of developing CRC, metastasis and/or tumor relapse based on said methylation status, wherein hypermethylation of said at least one CpG indicates an increased risk of developing CRC, metastasis and/or tumor relapse.
