Compounds derived from - 2 (1 - (2 - (2carbonil ethyl) benzyl) - pyrrolidin-3-yl 2il) - N - (4 - alquiloxazol carboxamide； use in the treatment of diseases involved in the response anttinflamatoria prostaglandin receptors.
MARTOS, JOSE L.,CARLING, WILLIAM R.,WOODWARD, DAVID F.,WANG, JENNY W.,KANGASMETSA, JUSSI J.
申请号：
CL2013000502
公开号：
CL2013000502A1
申请日:
2013.02.20
申请国别(地区):
CL
年份:
2014
代理人:
摘要：
The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy radicals. The compound may be represented by the following formula wherein R1 is selected from the group consisting of CO2R7 and CON(R7)SO2R7 wherein R1, R2, R3, R4, and R7 are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, EP3, TP and/or EP4 receptor mediated diseases or conditions.COMPUESTOS DERIVADOS DE 2-{1-[2-(2CARBONIL-ETIL)BENCIL]PIRROLIDIN-2IL}-N-ALQUILOXAZOL-4-CARBOXAMIDA； USO EN EL TRATAMIENTO DE ENFERMEDADES INVOLUCRADAS CON LA RESPUESTA ANTIINFLAMATORIA EN RECEPTORES DE PROSTAGLANDINA.
