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COMPOUNDS ACT AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE
专利权人:
William R. Carling;Jose L. Martos;Jenny W. Wang;Jussi J. Kangasmetsa;David F. Woodward
发明人:
Jose L. Martos,William R. Carling,David F. Woodward,Jenny W. Wang,Jussi J. Kangasmetsa
申请号:
US13213686
公开号:
US20120077858A1
申请日:
2011.08.19
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The present invention provides compounds, that are N-alkyl-2-(1-(5-substituted-2-(3-oxo-3-(trifluoromethylsulfonamido)propyl)benzyl)pyrrolidin-2-yl)oxazole-4-carboxamide wherein the 5 substituent is selected from the group consisting of halo and alkyloxy radicals. The compound may be represented by the following formulawherein R1 is selected from the group consisting of CO2R7 andCON(R7)SO2R7 wherein R1, R2, R3, R4, and R7 are as defined in the specification. The compounds may be administered to treat DP1, FP, EP1, EP3, TP and/or EP4 receptor mediated diseases or conditions.
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