BERGMANN, Andreas,MELANDER, Olle,MAGNUSSON, Martin
申请号：
EPEP2019/086844
公开号：
WO2020/128073A1
申请日:
2019.12.20
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Subject matter of the present invention is a method for assessing a risk in a subject having heart failure that is (i) the risk for getting a cardiovascular event and/or (ii) the risk of worsening heart failure condition and/or (iii) assessing the risk for mortality, in particular cardiovascular mortality, and/or (iv) assessing the risk of hospitalisation or re-hospitalisation due to having heart failure, comprising a) determining the level and/or the amount of Selenoprotein P and/or fragments thereof in a sample of said subject, b) correlating the determined level and/or the amount of Selenoprotein P and/or fragments thereof in a subject having heart failure with (i) the risk for getting a cardiovascular event and/or (ii) with the risk of worsening heart failure condition and/or (iii) with the risk for mortality, in particular cardiovascular mortality, and/or (iv) with the risk of hospitalisation or re-hospitalisation due to heart failure. Subject matter of the present invention includes stratification of patients and treatment methods for heart failure patients at high risk (i) for getting a cardiovascular event and/or (ii) of worsening heart failure condition and/or (iii) for mortality, in particular cardiovascular mortality, and/or (iv) of hospitalisation or re-hospitalisation due to heart failure.La présente invention a pour objet un procédé d'évaluation d'un risque chez un sujet ayant une insuffisance cardiaque qui est (i) le risque de survenue d'un événement cardiovasculaire et/ou (ii) le risque d'aggravation de l'état de l'insuffisance cardiaque et/ou (iii) l'évaluation du risque de mortalité, en particulier de mortalité cardiovasculaire, et/ou (iv) l'évaluation du risque d'hospitalisation ou de réhospitalisation en raison d'une insuffisance cardiaque, comprenant : a) la détermination du taux et/ou de la quantité de sélénoprotéine P et/ou de fragments de celle-ci dans un échantillon dudit sujet, b) la corrélation du taux déterminé et/ou de la quantité de sél
