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Use of polymer blends for the production of coated pharmaceutical forms, as well as pharmaceutical form with mixed polymer coating
专利权人:
Evonik Röhm GmbH
发明人:
MEIER, Christian,KNUPPEN, Karin,PETEREIT, Hans-Ulrich
申请号:
ES06723193
公开号:
ES2628962T3
申请日:
2006.03.03
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Use of a mixture consisting of 2 to 60% by weight of one or more polymers (I) with 40 to 98% by weight of one or more polymers (II), the polymer (I) being a copolymer of ( meth) acrylate, which contains 90 to 100% by weight of radical polymerized units of 66 to 95% by weight of C1- to C4-alkyl esters of acrylic or methacrylic acid, and 5 to 34 % of units of (meth) acrylate monomers with an anionic group, and 0 to 10% by weight of other vinyl polymerizable monomers, and the polymer (II) being a vinyl polymer other than the polymer (I) or a polysaccharide, or a derivative of a polysaccharide, containing 88 to 100% neutral monomer units and up to 12% by weight of polymerized monomer units with ionic moieties, the polymer (II) being a methacrylate copolymer of methyl and ethyl acrylate, a copolymer of methyl methacrylate, ethyl acrylate and tri ethyl methacrylate ethylammonium, polyvinyl acetate (PVAc), hydroxyethyl cellulose (HEC), ethyl cellulose (EC), or a mixture of said polymers, for the production of a coated pharmaceutical form, consisting of a core containing active product and a polymer coating consisting of the mixture of polymers (I) and (II), being able to add to the polymer mixture usual auxiliary substances, characterized in that the glass transition temperature of the polymer (I) does not rise to more than 70 ° C, and a release profile is obtained of active product, in which the active product, in comparison with a pharmaceutical form coated only with the polymer (I), is released starting with the same pH value, but in a delayed manner.Empleo de una mezcla constituida por un 2 a un 60 % en peso de uno o varios polímeros (I) con un 40 a un 98 % en peso de uno o varios polímeros (II), siendo el polímero (I) un copolímero de (met)acrilato, que contiene un 90 a un 100 % en peso de unidades polimerizadas por vía radicalaria de un 66 a un 95 % en peso de ésteres de C1- a C4-alquilo del ácido acrílico o metacrílico, y un 5 a un 34 % de unidades de monómeros de (
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