Schofield, Darren,Sleeman, Matthew Alexander,Chessell, Iain Patrick,Hatcher, Jonathan,Lowe, David
申请号：
HRP20200477
公开号：
HRP20200477T1
申请日:
2020.03.23
申请国别(地区):
HR
年份:
2020
代理人:
摘要：
This disclosure provides compositions and methods for controlling pain. In particular the disclosure provides a method for controlling pain comprising co-administration of an NGF antagonist and a TNFα antagonist. The NGF antagonist and the TNFα antagonist can be separate molecules or part of a multifunctional polypeptide, e.g., a multispecific binding molecule that comprises an NGF antagonist domain and a TNFα antagonist domain. This disclosure also provides multifunctional polypeptides, e.g., multispecific binding molecules, comprising an NGF antagonist domain, and a TNFα antagonist domain. The method provides improved pain control. Administration of an NGF antagonist and a TNFα antagonist as provided herein can control pain in the subject more effectively than an equivalent amount of the NGF antagonist or the TNFα antagonist administered alone.
