BAURIN, NICOLAS,BERNE, PIERRE-FRANCOIS,BLANCHE, FRANCIS,BONO, FRANCOISE,CAMERON, BEATRICE,DABDOUBI, TARIK,HERBERT, CORENTIN,MIKOL, VINCENT,REMY, ELISABETH
申请号：
NZ59086009
公开号：
NZ590860A
申请日:
2009.07.07
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is the FGF-R4 antagonist antibody comprising the CDRs of sequence SEQ ID Nos. 9, 10, 11, 12, 13 and 14； where one of the CDRs may differ by one or two amino acids compared with at least one of the sequences mentioned above, provided that the antibody keeps its binding specificity. Further disclosed is the FGF-R4 antagonist antibody comprising a variable light chain having at least 80% identity with one of the polypeptide sequences SEQ ID No. 30 or 32 and a variable heavy chain having at least 80% identity with a sequence SEQ ID No. 34, 36 or 38. Further disclosed are polynucleotides having a sequence having at least 80% identity with one of the sequences SEQ ID No.1, 3, 5, 7, 29, 31, 33, 35, or 37, provided that the polypeptide which it encodes keeps the binding specificity.
