The embodiments herein provide a method of synthesizing a novel enriched 10-boron drug for treatment of cancer by Boron Neutron Capture Therapy (BNCT) method. In BNCT, drug containing enriched 10-Boron has the important role in final treatment efficiency. The composition is Enriched 10-Boron Calcium Fructo Borate (E10BCFB). The Calcium Fructo-Borate is found in some vegetables. E10BCFB is in fact an artificial Calcium Fructo-Borate which is synthesized chemically with enriched 10-Boron. E10BCFB becomes an important competitor drug in the fight against some cancerous cells. The composition is applied orally and parenterally.