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4-fluoro-thio-containing inhibitors of APP2, compositions thereof and method of use
专利权人:
Simmons, William
发明人:
Simmons, William H.
申请号:
AU20150354761
公开号:
AU2015354761(B2)
申请日:
2015.10.30
申请国别(地区):
澳大利亚
年份:
2018
代理人:
摘要:
The present invention has multiple aspects. In its first aspect, it is directed to a compound that is a 4(S)-fluoro-thio-tripeptide analog that has the unexpectedly superior property of specifically inhibiting the enzyme, membrane-bound aminopeptidase P2 (APP2), whose natural substrate is bradykinin, but not the enzyme angiotensin converting enzyme (ACE) which also cleaves bradykinin. In its second aspect, the present invention is directed to a pharmaceutical composition comprising the 4(S)-fluoro-thio-tripeptide analog and a pharmaceutically acceptable carrier. In its third aspect, the invention is directed to a method of inhibiting bradykinin degradation in a mammalian patient, comprising administering a therapeutically effective amount of the compound of the invention to a mammalian patient in need of inhibition of bradykinin degradation.
来源网站:
中国工程科技知识中心
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