CASE WESTERN RESERVE UNIVERSITY ;THE CLEVELAND CLINIC FOUNDATION
发明人:
Perez Victor L.,Hollyfield Joe G.,Salomon Robert G.
申请号：
US201815894782
公开号：
US2018160660(A1)
申请日:
2018.02.12
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
The invention is directed to a method of producing a non-human mammal having one or more pathological characteristics of retinal degeneration and/or age-related macular degeneration. In particular, the invention provides a method of producing a non-human mammal having age-related macular degeneration (AMD). The invention is also directed to non-human animals produced by the methods described herein. Methods of identifying an agent for use in inhibiting one or more pathological characteristics of retinal degeneration and/or AMD is also encompassed by the invention. Also provided is a method of treating AMD in an individual in need thereof comprising, administering to the individual an agent identified herein.
