MILTENYI BIOTEC B.V. & CO. KG;CHARITE-UNIVERSITATSMEDIZIN BERLIN
发明人:
NOWAK, ANNA,LOCK, DOMINIK,KAISER, ANDREW,SCHEFFOLD, ALEXANDER
申请号：
CA3088832
公开号：
CA3088832A1
申请日:
2019.01.17
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
The present invention provides a regulatory T (Treg) cell expressing an antigen chimeric receptor (CAR) comprising a) at least one antigen binding domain, b) a transmembrane domain, and c) a cytoplasmic signaling domain comprising at least one primary cytoplasmic signaling domain and at least the co-stimulatory signaling domain of CD137, wherein said antigen binding domain specifically binds an antigen that is expressed on the surface of a target cell or a tag of a tagged polypeptide that binds to an antigen expressed on the surface of a target cell or a soluble antigen. Compositions comprising said Treg cells, and methods of enrichment and analysis of activated Tregs that express said CAR are also disclosed.
