The present invention, in certain embodiments, suppresses tyrosinase expression, and thus RNA complexes useful for the treatment of pigmentation related disorders associated with reduced melanin production and excessive melanin production, such as melanosis and age-related plaques ( For example, asymmetric RNA complexes such as asiRNA and lasiRNA) are provided. [Selection] Figure 1本発明は、特定の態様において、チロシナーゼ発現を抑制し、したがってメラニン産生の低減および過剰なメラニン産生に関連した色素沈着関連障害、例えば黒皮症および加齢斑の治療に有用なRNA複合体(例えば非対称RNA複合体、例えばasiRNAおよびlasiRNA)を提供する。【選択図】図1