The present invention is directed to pharmaceutical compositions, and methodsof making such compositions,wherein the compositions comprise a plurality of TPR and RR particles,wherein: the TPR particles each comprise a core coatedwith a TPR layer； the core comprises a weakly basic, poorly soluble drug and apharmaceutically acceptable organic acid separatedfrom each other by an SR layer； the RR particles each comprise the weaklybasic, poorly soluble drug, and release at leastabout 80 wt.% of the weakly basic, poorly soluble drug in about 5 minutes whendissolution tested using United States Pharmacopoeia(USP) dissolution methodology (Apparatus 2 - paddles@ 50 RPM and a two-stagedissolution medium at 37°C (first 2hours in 0.1N HCl followed by testing in a buffer at pH 6.8).
