Mayo Foundation for Medical Education and Research;Nantibodyfc, LLC
发明人:
Swiss, Gerald F.,Markovic, Svetomir N.,Nevala, Wendy K.
申请号：
AU2016335502
公开号：
AU2016335502A1
申请日:
2016.04.06
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
Described herein are methods, formulations and kits for treating a patient with cancer with anti-VEGF antibodies and albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes. In another aspect, provided herein are methods for enhancing the efficacy of albumin-bound chemotherapeutic/anti-VEGF antibody nanoparticle complexes. In another aspect, provided herein are methods for enhancing the therapeutic outcome in a patient suffering from a cancer expressing soluble VEGF which patient is selected to be treated with nanoparticles comprising albumin-bound paclitaxel and anti-VEGF antibodies wherein said antibodies of the nanoparticles are integrated onto and/or into said nanoparticles which method comprises treating said patient with a subtherapeutic amount of said anti-VEGF antibody prior to any subsequent treatment with the nanoparticles.
