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Anti CCL20 monoclonal antibody or a fragment of the same Union; Nucleic Acid Molecule that encodes; vector; host Cell; production method, composition containing same and its use.
专利权人:
LTD.;EISAI R&D MANAGEMENT CO.
发明人:
IMAI, TOSHIO,KLINE, JAMES BRADFORD,KAWANO, TETSU,SAKAMOTO, YOSHIMASA,GRASSO, LUIGI,SPIDEL, JARED,NISHIMURA, MIYUKI,MURAMOTO, KENZO,HORIZOE, TATSUO
申请号:
CL2013001403
公开号:
CL2013001403A1
申请日:
2013.05.17
申请国别(地区):
CL
年份:
2014
代理人:
摘要:
The present invention relates to novel humanized, chimeric and murine antibodies that have binding specificity for the human CC chemokine ligand 20 (CCL20). The present invention further relates to heavy chains and light chains of said antibodies. The invention also relates to isolated nucleic acids, recombinant vectors and host cells that comprise a sequence which encodes a heavy chain and/or a light chain of said antibodies, and to a method of preparing said antibodies. The anti-CCL20 antibodies of the invention can be used in therapeutic applications to treat, for example, inflammatory and autoimmune disorders and cancer.<;p>;THE PRESENT INVENTION RELATES TO NOVEL HUMANIZED, CHIMERIC AND MURINE ANTIBODIES THAT HAVE BINDING SPECIFICITY FOR THE HUMAN CC CHEMOKINE IIGAND 20 (CCL20). THE PRESENT INVENTION FURTHER RELATES TO HEAVY CHAINS AND LIGHT CHAINS OF SAID ANTIBODIES. THE INVENTION ALSO RELATES TO ISOLATED NUCLEIC ACIDS, RECOMBINANT VECTORS AND HOST CELLS THAT COMPRISE A SEQUENCE WHICH ENCODES A HEAVY CHAIN AND/OR A LIGHT CHAIN OF SAID ANTIBODIES, AND TO A METHOD OF PREPARING SAID ANTIBODIES. THE ANTI-CCL20 ANTIBODIES OF THE INVENTION CAN BE USED IN THERAPEUTIC APPLICATIONS TO TREAT, FOR EXAMPLE, INFLAMMATORY AND AUTOIMMUNE DISORDERS AND CANCER.<;/p>;
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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