Biogenic sulfide production is synergistically inhibited by treating sulfate-reducing bacteria (SRB) with a biocide and a metabolic inhibitor. The biocidedirectly kills a first portion of the SRB. The metabolic inhibitor inhibitssulfate-reducing growth of a second portion of the SRB without directlykilling the second portion of the SRB. The treatment of SRB with both abiocide and a metabolic inhibitor provides effective biogenic sulfideinhibition at significantly lower concentrations than would be required if thebiocide or metabolic inhibitor was used alone.