PROBLEM TO BE SOLVED: To provide a manufacturing method of a multi-layered capsule which contains two types of active pharmaceutical ingredient, and is isolated by having a multilayer structure in the capsule, and a multi-layered capsule.SOLUTION: In a multi-layered capsule, a first compartment 61 and a second compartment 62 respectively contain a first homogeneous material 51 and a second homogeneous material 52, and a barrier layer 50 isolates the first homogeneous material 51 from the second homogeneous material 52. A manufacturing method of a multi-layered capsule includes: a process of adding the first homogeneous material, the second homogeneous material, and the barrier layer 50 to an internal space of a capsule body a process of adding the barrier layer 50 to the front or rear of the first homogeneous material a process of attaching at least one cover body on at least one opening of a body and the like. The multi-layered capsule includes the barrier layer arranged in the internal space of the capsule body in order to separate the first compartment 61 containing the first homogeneous material and the second compartment 62 containing the second homogeneous material 52, and the barrier layer is mineral oil and paraffin wax.SELECTED DRAWING: Figure 1C
