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COMPOSITIONS INCLUDING GALLATES AND GALLAMIDES
专利权人:
КОЛГЕЙТ-ПАЛМОЛИВ КОМПАНИ (US)
发明人:
ЯРАЦЗ Станислав (US),СЮЙ Гофэн (US),МИЛЛЕР Стивен (US),ЛИ Леонора (US),ПИКЕ Гийом (US),ДЮ-ТЮММ Лоранс (US)
申请号:
RU2014129876
公开号:
RU2014129876A
申请日:
2012.12.17
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. An oral composition for topical use containing an antibacterial effective concentration of a gallate or gallamide compound which is a polysubstituted cycloalkyl, where the substituents are selected from hydroxy, hydroxymethyl, fluorine, chlorine, amino, nitro or a fragment of the formula -X- (CO) - (3,4,5-trihydroxyphenyl), where X is selected from O or NH, with the proviso that the substituents include at least two fragments of the formula -X- (CO) - (3,4,5-trihydroxyphenyl), attached to adjacent carbon atoms; in free form or in the form of an oral or locally acceptable salt. 2. The composition of claim 1, wherein the gallate or gallamide compound is a compound of formula 1: wherein X is O or NH, A is cyclopentyl, cyclohexyl optionally substituted with one or more substituents selected from one or more hydroxy, hydroxymethyl or a fragment formulas -X- (CO) - (3,4,5-trihydroxyphenyl); in free form or in the form of an oral or locally acceptable salt. 3. The composition of claim 1, wherein X is O.4. The composition of claim 1, wherein X is NH.5. The composition according to PP. 1-4, where A represents cyclohexyl or cyclopentyl. 6. The composition of claim 1, wherein the gallate or gallamide compound is selected from trans-1,2-cyclohexanediol digallate (THDG), cis-1,2-cyclohexanediol digallate (CHDG), cis-1,2-cyclopentanediol digallate (CPDG), trans-1, 2-cyclohexanedigallamide (THDGA) and cis-1,2-cyclohexanedigallamide (CHDGA) and mixtures thereof. 7. The composition of claim 6, wherein the gallate or gallamide compound is selected from trans-1,2-cyclohexanediol digallate (THDG), cis-1,2-cyclohexanediol digallate (CHDG), and mixtures thereof. The composition of claim 1, further comprising a surfactant, antioxidant and / or buffer. The composition of claim 1, wherein the antibacterial1. Композиция для ухода за полостью рта для местного применения, содержащая антибактериально эффективную концентрацию соединения галлата или галламида, которое является полизамещенным ц
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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