This invention, the new oxime derivative general formula (i), glutamic acid operation Characteristic signal transmission with the medicine constituent, and the mammal which include those and/or when it is related to the change of function, and/or remedies a state where it has glutamic acid level or the possibility of receiving influence to change of signal transmission and/or offers the use in order to prevent. This invention furthermore, by the fact that adjustment factor of the nervous system receptor which has sensitivity in glutamic acid is included, acuteness and chronic nervous study and/or remedy of the spiritual especially ideal, offers the new oxime derivative general formula (i) medical disorder and/or to prevention. With execution configuration of specification, as for the new oxime derivative of this invention, it is adjustment factor of the metabolism die glutamic acid receptor (mGluR). This invention furthermore, the positive allosteric adjustment factor of mGluR, and further in details, offers the positive allosteric adjustment factor of mGluR4.本発明は、一般式(I)の新規オキシム誘導体、それらを含む医薬組成物、及び、哺乳動物でのグルタミン酸作動性シグナル伝達及び/又は機能の変化に関連する状態、及び/又はグルタミン酸レベル若しくはシグナル伝達の変化に影響を受ける可能性のある状態を治療する及び/又は予防するためのその使用を提供する。本発明はさらに、グルタミン酸に感受性をもつ神経系受容体の調節因子を含むことで、急性及び慢性の神経学的及び/又は精神医学的障害の治療及び/又は予防に特に好適な、一般式(I)の新規オキシム誘導体を提供する。特定の実施形態では、本発明の新規オキシム誘導体は、代謝型グルタミン酸受容体(mGluR)の調節因子である。本発明はさらに、mGluRの正のアロステリック調節因子、及びより具体的には、mGluR4の正のアロステリック調節因子を提供する。
