JAESCHKE, GEORG,LINDEMANN, LOTHAR,STADLER, HEINZ,VIEIRA, ERIC
申请号：
PH12015500538
公开号：
PH12015500538B1
申请日:
2015.03.12
申请国别(地区):
PH
年份:
2015
代理人:
摘要：
The present invention relates to ethynyl derivatives of formula (I) wherein R1 is phenyl, 3-fluorophenyl, 4-fluorophenyl or 2,5-di-fluorophenyl or to a pharmaceutically acceptable acid addition salt, in enantiomerically pure form with the absolute configuration as shown in formula I. It has now surprisingly been found that the compounds of general formula I are allosteric modulators of the metabotropic glutamate receptor subtype 5 (mGluR5) which show advantageous biochemical-, physicochemical- and pharmacodynamic- properties compared to compounds of prior art.
