Marina Cardó-Vila;Wadih Arap;Ana Paula Valente;Renata Pasqualini;Ricardo Giordano;Fabio Ceneviva Lacerda De Almeida
发明人:
Renata Pasqualini,Wadih Arap,Ricardo Giordano,Marina Cardó-Vila,Ana Paula Valente,Fabio Ceneviva Lacerda De Almeida
申请号：
US12672647
公开号：
US20120028880A1
申请日:
2008.08.08
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention concerns the fields of molecular medicine and targeted delivery of therapeutic agents. More specifically, the present invention relates to the identification of novel peptide sequences that incorporate the amino acids Leu-Pro-Arg (LPR), and particularly D(LPR), that selectively target VEGFR-I and NRP-I expressing cells. Targeted molecules in accor-dance with the invention are useful in the treatment and detection of neovascular or angiogenic VEGF associated disorders, including but not limited to cancer, obesity, diabetes, asthma, arthritis, cirrhosis and ocular diseases.
