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人工多能性幹細胞を腸管上皮細胞へ分化誘導する方法
专利权人:
公立大学法人名古屋市立大学
发明人:
岩尾 岳洋,松永 民秀
申请号:
JP2015502917
公开号:
JP6296399B2
申请日:
2014.02.24
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
The purpose of the present invention is to provide a novel method for efficiently inducing the differentiation of induced pluripotent stem cells into intestinal epithelial cells, and a use thereof. The differentiation of induced pluripotent stem cells into intestinal epithelial cells is induced by: a step in which induced pluripotent stem cells are differentiated into endoderm-like cells a step in which the endoderm-like cells obtained at the aforementioned step are differentiated into intestinal stem cell-like cells and a step in which the intestinal stem cell-like cells obtained at the aforementioned step are differentiated into intestinal epithelial cell-like cells, said step including culturing in the presence of EGF and at least one compound selected from the group consisting of MEK1 inhibitors, DNA methylation inhibitors, and TFG&bgr receptor inhibitors.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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