MACDONALD, Lynn L,MURPHY, Andrew J. AJ,VORONINA, Vera V,GURER, Cagan C,‧麥克唐納,‧莫菲,‧沃羅寧那,‧古雷爾
申请号：
HK16102631.3
公开号：
HK1214613A
申请日:
2016.03.08
申请国别(地区):
HK
年份:
2016
代理人:
摘要：
The invention provides genetically modified non-human animals that express chimeric human/non-human MHC I and MHC II polypeptides and/or human or humanized 2 microglobulin polypeptide, as well as embryos, cells, and tissues comprising the same. Also provided are constructs for making said genetically modified animals and methods of making the same. Methods of using the genetically modified animals to study various aspects of human immune system are provided.
