OBSHCHESTVO S OGRANICHENNOY OTVETSTVENNOSTYU "VIK - ZDOROVYE ZHIVOTNYKH"
发明人:
Boris Viktorovich VIOLIN,Sergey Vyacheslavovich SEMENOV,Dmitriy Vladimirovich PRISTENSKIY,Aleksandr Andreevich ANISKOV
申请号：
US15792970
公开号：
US20180042953A1
申请日:
2017.10.25
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The invention relates to the field of veterinary science and medicine and can be used for the prophylaxis and treatment of bacterial infections. The aim of the present invention is to design a preparation based on azithromycin in the form of a solution, having a wide spectrum of antimicrobial activity, and in the form of an injection solution ready for use not only for introduction intravenously, but also for intramuscular, subcutaneous, intrauterine and intracisternal introduction. The antibacterial pharmaceutical composition comprises azithromycin, a pH adjuster, solvents and/or cosolvents, a preservative, and an antioxidant. The antioxidant is in the form of thioglycerol, sodium ascorbate, 4-methyl-2,6-di-tert-butylphenol, 2,4,5-trihydroxybutyrophenone, and combination thereof, whereas the preservative is in the form of chloroethon or benzyl alcohol with the following ratios of components by percentage mass: 5-30% azithromycin, up to 5% pH adjuster, 0.5-1% preservative, 0.1-0.2% antioxidant, the remainder being solvents.
