Gabriel Martinez Botella,Boyd L. Harrison,Albert Jean Robichaud,Francesco G. Salituro,Richard Thomas Beresis
申请号：
US16778975
公开号：
US20200165291A1
申请日:
2020.01.31
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided herein are 19-nor C3,3-disubstituted steroids of Formula (I):and pharmaceutically acceptable salts thereof； wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
