BOTELLA, Gabriel Martinez,HARRISON, Boyd L.,ROBICHAUD, Albert Jean,SALITURO, Francesco G.,BERESIS, Richard Thomas
申请号：
EP15799762
公开号：
EP3149018A4
申请日:
2015.05.29
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I) : and pharmaceutically acceptable salts thereof wherein R1, R2, R3, and R4are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
