#$%^&*AU2017100590A420170622.pdf#####ABSTRACT The present invention provides a method of preparing a crystalline copper-based coordination polymer comprising and especially preferably but not exclusively comprising and in particular essentially consisting of repeating coordination entities extending in three 5 (3D) dimensions. The crystalline copper-based coordination polymer obtained or obtainable by the method proved to be especially suitable for providing a sensing platform for detecting the presence of one or more target nucleic acid sequences such as viral RNA, in particular Dengue virus and/or Zika virus RNA with high selectivity and high specificity. The present invention, thus, also provides a method of detecting at least a first target nucleic acid 0 sequence in a sample. The target nucleic acid sequence is in particular from a viral RNA, in particular it is Flavivirus RNA. Especially preferably but not exclusively, the method is for detecting a first and a second target nucleic acid sequence in the sample, which first target nucleic acid is Dengue virus RNA and which second nucleic acid sequence is Zika virus RNA. Further provided is a kit, which comprises the crystalline copper-based coordination 5 polymer and an oligonucleotide probe and its use.immerse in water for 48h as-synthesized a....e ... .... . simulated 10 io io 4o 5o 20 (degree) Fig. 1A 10080. S6040206 15C 306 450 600 750 900 Temperature (C) Fig. 1B
