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ANTIBACTERIAL BASIC BIAROMATIC DERIVATIVES WITH AMINOALKOXY SUBSTITUTION
专利权人:
IDORSIA PHARMACEUTICALS LTD
发明人:
申请号:
EP15778983.5
公开号:
EP3207042B1
申请日:
2015.10.14
申请国别(地区):
EP
年份:
2018
代理人:
摘要:
Claim 1: a compound of the formula (1): where n represents 0, 12 or 3 r\u00b9\u1d43 represents H or alkyl c\u2081\u208b\u2083 r\u00b2\u1d43 and r\u00b2\u1d47 independently represent H or alkyl c\u2081\u208b\u2083 r\u00b3\u1d43 and r\u00b3\u1d47 independently represent H or c\u2081\u208b\u2083 r\u2074 represents alkylC\u2081\u208b\u2083 h, alkyl, alkyl - or c\u2082\u208b\u2083 nr\u2074\u1d43r\u2074\u1d47, where r\u2074\u1d43 and r\u2074\u1d47 are independently H or alkyl c\u2081\u208b\u2083 among themselves r\u2075 c\u2081\u208b\u2083 represents h, alkyl, alkyl - or c\u2082\u208b\u2083 nr\u2075\u1d43r\u2075\u1d47,Where r\u2075\u1d43 and r\u2075\u1d47 are independently H or alkyl c\u2081\u208b\u2083 between themselves or r\u00b2\u1d43 and r\u00b2\u1d47 along with the carbon Atom to form a cycloalkyl Ring holder of 3 to 6 members or r\u2074 and together with the r\u2075NITROGEN Atom to form a Ring Holder heterocicloalquilo 4-6 members or r\u2074 and r\u2075 along with the nitrogen Atom to form a Ring Holder heterocicloalquilo anologue of 6 to 8 mMember, where the heterocicloalquilo bicyclic Ring can be optionally replaced with a Group nr\u2076r\u2077,Where r\u2076 and r\u2077 are independently H or alkyl c\u2081\u208b\u2083 between themselves or r\u2074 and r\u2075 along with the nitrogen Atom and the adjacent to the Porta cr\u00b2\u1d43r\u00b2\u1d47 or cr\u00b3\u1d43r\u00b3\u1d47 together form an amidine or r\u00b9\u1d43 Group and R\u00b3\u1d43, together with the carbon Atoms that carry and the carbon Atom that connects these two ATOMS, forming a cycloalkyl Ring of 4 to 6 members, where r\u00b2\u1d43,R\u00b2\u1d47 and r\u00b3\u1d47 independently represent h, and N represents 1 or r\u00b9\u1d43 r\u2074 and, together with the Carbon and Nitrogen Atoms that carry and carbon Atoms Connecting the two Atoms.Heterocicloalquilo form a Ring of 4 to 6 members, where r\u00b2\u1d43, r\u00b2\u1d47 and optional, Optional r\u00b3\u1d43 r\u00b3\u1d47 independently represent h, N repr
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